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Heller, W., Musil, H

2014 Jun;34(3):284-90.

For example, toll like receptor 4 (TLR4)-activated macrophages show increased expression of histone deacetylase 1 (HDAC1), a response dependent on type I interferon (IFN) signaling

Of these 36 studies, 35 were preclinical animal experiments

Additionally, TFR1, acyl-CoA synthetase family member 2 (ACSF2), and heme oxygenase-1 (HO-1) expression were significantly upregulated, leading to increased ferroptosis in the optic nerves of locally demyelinated MS mice

Instead, cellular uptake is expected to occur primarily through clathrin-mediated endocytosis and macropinocytosis, facilitated by its small size